There are about a dozen industries at the frontier of innovation. They include software and pharmaceuticals, semiconductors and data processing. Most of their workers have science or tech degrees. They invest heavily in research and development. While they account for only 3 percent of all jobs, they account for 6 percent of the country’s economic output.A few cities have gained most of the jobs in these industries (Seattle, SF, San Diego, Boston, Silicon Valley) while many cities have lost jobs.
The article has a map showing the gains and losses in thousands of jobs. My home area, known as the "Triple Cities" (i.e., Binghamton, Endicott, Johnson City) is one of the big losers according to the map, though I don't find the specific statistics.
When I was growing up, the cities had Endicott Johnson (shoes, long gone) as the leading employer, but IBM was second, Link (producer of the Link Trainer) was there. Scintilla was in Sidney.
I believe none of these companies are left--IBM deserting its ancestral home for the greener pastures of Poughkeepsie and other sites.
I don't know what the major employers in the area are now--I suspect education and health.