Who is appointed and confirmed to the Supreme Court is very significant. My spouse is very concerned. The senators who seem to be key are Collins and Murkowski on the Republican side, who presumably would not want an appointee certain to overturn Roe. And on the Democratic side, the WV, ND, MO, and IN senators who might want to polish their non-partisan credentials by voting for a Trump appointee.
Ideologues on both sides want to oust the RINOs and DINOs in their party. The more they do so (no Jacob Javits or Hugh Scott in today's Republican party) the more power the remaining individuals have.
It's similar to the maneuvering within the Court itself. Back in the old days, Sandra Day O'Connor was the swing vote, and Kennedy was just a slightly less conservative than his fellows on the right. O'Connor retires, promoting Kennedy into the swing position. Kennedy retires, and the conventional wisdom is that Chief Justice Roberts becomes the swing.